DES(1-3)IGF-1
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IGF-1 DES is a truncated IGF-1 analog missing its first three amino acids, which reduces its binding to IGFBPs and makes it roughly ten times more potent than native IGF-1 at the receptor, paired with a very short (~20-30 minute) half-life. Bodybuilders inject it locally post-workout hoping for site-specific hypertrophy, but there are no human trials of this analog for muscle growth and the practice rests on receptor-biology extrapolation and anecdote. It is distinct from the more commonly used IGF-1 LR3.
